the effect of cumin cyminum l. plus lime administration on weight loss and metabolic status in overweight subjects: a randomized double-blind placebo-controlled clinical trial

background limited data are available regarding the effects of combined administration of cumin cyminum l. and lime on weight loss and metabolic profiles among subjects with overweight subjects. objectives the current study aimed to assess the effects of combined administration of cumin cyminum l. and lime on weight loss and metabolic profiles among subjects with overweight. patients and methods this randomized double-blind placebo-controlled clinical trial was conducted on 72 subjects with overweight, aged 18 - 50 years old. participants were randomly divided into three groups: group a received high-dose cumin cyminum l. and lime capsules (75 mg each, n = 24), group b low-dose cumin cyminum l. and lime capsules (25 mg each, n = 24) and group c placebos (n = 24) twice daily for eight weeks. results after eight weeks of intervention, compared with low-dose c. cyminum l. plus lime and placebo, taking high-dose c. cyminum l. plus lime resulted in significant weight loss (in the high-dose group: -2.1 ± 1.7 vs. in the low-dose group: -1.2 ± 1.5 and in the placebo group: + 0.2 ± 1.3 kg, respectively; p < 0.001) and body mass index (-0.8 ± 0.6 vs. -0.5 ± 0.5 and +0.1 ± 0.5 kg/m2, respectively; p < 0.001). in addition, administration of high-dose c. cyminum l. plus lime compared with low-dose c. cyminum l. plus lime and placebo, led to a significant reduction in fasting plasma glucose (fpg) (p < 0.001) and a significant rise in quantitative insulin sensitivity check index (quicki) (+ 0.02 ± 0.02 vs. + 0.01 ± 0.02 and 0.01 ± 0.01, respectively; p = 0.01). moreover, a significant decrease in serum triglycerides (-14.1 ± 56.2 vs. +13.9 ± 36.8 and + 10.6 ± 25.1 mg/dl; respectively; p = 0.03), total-cholesterol (-18.4 ± 28.6 vs. +8.6 ± 28.5 and -1.0 ± 24.8 mg/dl; respectively; p = 0.004) and low density lipoproteins- (ldl)-cholesterol levels (-11.8 ± 20.7 vs. +6.5 ± 23.2 and -2.9 ± 20.4 mg/dl, respectively; p = 0.01) was observed following the consumption of high-dose c. cyminum l. plus lime compared with low-dose c. cyminum l. plus lime and placebo. conclusions results of the current study indicated that taking high-dose c. cyminum l. plus lime for eight weeks among subjects with overweight had beneficial effects on weight, bmi, fpg, quicki, triglycerides, total-cholesterol and ldl-cholesterol levels.